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_______________, rather than ______________, are becoming the leading causes of disability and premature death worldwide.


A) Chronic conditions such as cardiovascular disease; infectious diseases such as malaria
B) Infectious diseases such as malaria; chronic conditions such as cardiovascular disease
C) Traffic deaths; infectious diseases such as malaria
D) Chronic conditions such as cardiovascular disease; traffic deaths
E) Infectious diseases such as malaria; traffic deaths

F) A) and B)
G) A) and C)

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Diseases usually develop in response to _______ factors.


A) Nutritional and diet
B) Infectious or toxic
C) Physical
D) Psychological stress
E) All of these are correct

F) C) and D)
G) All of the above

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Teratogens cause abnormal growth specifically in


A) Nerve cells
B) Muscle cells
C) Embryos
D) The liver
E) Skin cells

F) C) and E)
G) C) and D)

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Individuals represented by the right end of the dose/response curve (responding to doses between 30 and 40 ppm) are ____________ to the chemical.


A) Very sensitive
B) Very insensitive
C) About average in sensitivity
D) Relatively insensitive
E) Relatively sensitive

F) A) and B)
G) A) and C)

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Neurotoxins act by


A) Disrupting nerve cells
B) Altering genetic material
C) Repressing the immune system
D) Disrupting normal hormone functions
E) Causing abnormalities in nervous tissue during embryonic growth and development

F) B) and E)
G) B) and C)

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Two problems encountered in human health risk assessment are _______________________ and ___________________.


A) Use of chemical mixtures; lack of knowledge about synergistic effects
B) Lack of funding for federal mandates; lack of public support
C) Extrapolation of data to low doses; extrapolation of data from nonhuman species to humans
D) Lack of planning; the involvement of politics
E) There are no inherent problems in human health risk assessment

F) All of the above
G) D) and E)

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Bioaccumulation is important because it allows cells to


A) Accumulate essential nutrients and minerals
B) Rid themselves of waste material
C) Protect themselves against toxins
D) Reproduce more quickly
E) Have a ready source of energy if it is needed

F) B) and E)
G) A) and B)

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An LD50 is a dose of a toxic chemical that


A) Is an acceptable level of risk for most individuals
B) All individuals react to
C) Kills individuals 50 years old and obove
D) Is 50 times less than the minimal dose
E) Kills half of the population

F) B) and E)
G) C) and E)

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Endocrine disruptors


A) Disrupt nerve cells
B) Alter genetic material
C) Repress the immune system
D) Disrupt normal hormone functions
E) Cause abnormalities in nervous tissue during embryonic growth and development

F) All of the above
G) B) and E)

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Which of the following practices contributes the least to antibiotic or pesticide resistance?


A) Domestic farm animals are fed low doses of antibiotics to increase weight gain.
B) A person takes the full course of the appropriate antibiotic when she has a viral infection.
C) A person takes the full course of the appropriate antibiotic when she has a bacterial infection.
D) A person takes an anti-malarial drug when he does not have malaria.
E) Mosquito populations in the tropics have been sprayed with DDT for about 50 years.

F) C) and D)
G) A) and B)

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Highly persistent toxic chemicals


A) Retain their toxicity as they cycle through the food chain and environment
B) Lose their toxicity once released in the environment
C) Accumulate within one organism but break down at higher trophic levels
D) Are highly unusual among artificial chemicals
E) Are usually not that toxic in their life span

F) A) and C)
G) A) and E)

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Fetal alcohol syndrome is caused by exposure to a(n)


A) Neurotoxin
B) Mutagen
C) Antigen
D) Teratogen
E) Allergen

F) A) and E)
G) C) and D)

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Chronic effects of a toxic response


A) Are less harmful than acute effects
B) Can last a long time or be permanent
C) Rarely show up in time to be diagnosed
D) Are unlikely to be lethal
E) Are likely to kill the individual during the initial exposure

F) A) and B)
G) B) and E)

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How many substances is the EPA responsible for monitoring?


A) 657
B) 500
C) 275
D) 1,000

E) A) and D)
F) A) and C)

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Pathogenic organisms are those that cause diseases.

A) True
B) False

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Allergens are substances that


A) Repress the immune system
B) Stimulate the nervous system
C) Prevent oxygen uptake
D) Activate the immune system
E) Interfere with oxygen uptake

F) B) and C)
G) A) and E)

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An advantage of testing for toxicity by exposing animals to chemicals is that using animals is


A) Cheaper than other methods
B) Faster than other methods
C) Usually quite humane
D) Easier than using computer models
E) A trusted and usually reliable way to get results

F) A) and C)
G) A) and D)

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Acute effects of a toxin appear


A) Only after repeated exposure
B) Long after exposure
C) Immediately after exposure
D) When there is sustained contact
E) To cause permanent damage if the individual survives the initial exposure

F) B) and D)
G) B) and E)

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Between 1990 and 2010, what showed the biggest rank increase for the "Leading Causes of Global Disease Burden?"


A) HIV/AIDS
B) Stroke
C) Diabetes
D) Malaria

E) C) and D)
F) B) and D)

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Toxins can be dangerous in very small concentrations.

A) True
B) False

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